髓过氧化物酶-过氧化氢-氯离子（MPO-H2O2-C1-）系统介导的氯化、脱羧和杀菌活性。

Chlorination, decarboxylation and bactericidal activity mediated by the MPO-H2O2-C1- system.

Sbarra A J, Selvaraj R J, Paul B B, Zgliczynski J M, Poskitt P K, Mitchell G W, Louis F

Adv Exp Med Biol. 1976;73 PT-A:191-203. doi: 10.1007/978-1-4684-3297-8_17.

Abstract

MPO, H2O2 and C1- form a complex that undergoes intramolecular rearrangement yielding the chlorinium ion. 2. The chlorinium ion can interact with MPO, bacteria and amino acids. 3. The reaction can occur at a wide range of pH, H2O2 concentration and C1- concentration. 4. The chlorinium ion can attack different protein molecules to cause structural changes. 5. Preincubation of MPO with bacteria results in greater bactericidal activity. 6. Diffusible bactericidal agents are also produced by the MPO-H2O2-C1- system.

摘要

髓过氧化物酶（MPO）、过氧化氢（H2O2）和氯离子（C1-）形成一种复合物，该复合物发生分子内重排，产生氯鎓离子。2. 氯鎓离子可与髓过氧化物酶、细菌和氨基酸相互作用。3. 该反应可在广泛的pH值、过氧化氢浓度和氯离子浓度范围内发生。4. 氯鎓离子可攻击不同的蛋白质分子，导致结构变化。5. 髓过氧化物酶与细菌预孵育会产生更强的杀菌活性。6. 髓过氧化物酶-过氧化氢-氯离子系统还会产生可扩散的杀菌因子。