Binnion P F, DasGupta R
Int J Clin Pharmacol Biopharm. 1975 Jul;12(1-2):96-101.
Digitalis-induced arrhythmias can be suppressed by intravenous potassium, diphenylhydantoin sodium and propranolol. As it is known that hyperkalemia can interfere with the myocardial uptake of digoxin, this study was performed to determine whether diphenylhydantoin sodium or propranolol could exert any antiarrhythmic effect by altering the metabolism of 3H-digoxin and, in particular, the accumulation of the glycoside by cardiac muscle. Three groups of anesthetized dogs were given 6 muCi 3H-digoxin per kilogram intravenously, and in two groups 15 mg/kg diphenylhydantoin sodium or 3 mg/kg propranolol were injected intravenously 15 minutes prior to the glycoside. The concentration of labelled digoxin was measured in plasma up to one hour, and then tissues were removed and analyzed for digoxin content. Diphenylhydantoin sodium did not influence myocardial uptake of digoxin. It is considered its suppressant action on digitalis-induced arrhythmias is not due to any effect on the cardiac accumulation of digoxin. Propranolol did reduce the myocardial uptake of digoxin, but this was not considered of sufficient magnitude to be the main factor in suppressing arrhythmias induced by digitalis. These studies provide evidence that both diphenylhydantoin sodium and propranolol do not have a suppressant effect on digitalis-induced arrhythmias by virtue of any significant interference with the uptake of digoxin by myocardial tissue.
静脉注射钾、苯妥英钠和普萘洛尔可抑制洋地黄引起的心律失常。由于已知高钾血症会干扰心肌对洋地黄毒苷的摄取，因此进行本研究以确定苯妥英钠或普萘洛尔是否可通过改变3H-洋地黄毒苷的代谢，尤其是心肌对糖苷的蓄积，发挥任何抗心律失常作用。给三组麻醉犬静脉注射每千克6微居里的3H-洋地黄毒苷，在两组中，在注射糖苷前15分钟静脉注射15毫克/千克苯妥英钠或3毫克/千克普萘洛尔。在长达一小时的时间内测定血浆中标记洋地黄毒苷的浓度，然后取出组织并分析洋地黄毒苷含量。苯妥英钠不影响心肌对洋地黄毒苷的摄取。认为其对洋地黄引起的心律失常的抑制作用并非由于对洋地黄毒苷在心脏蓄积的任何影响。普萘洛尔确实减少了心肌对洋地黄毒苷的摄取，但这一减少幅度被认为不足以成为抑制洋地黄引起的心律失常的主要因素。这些研究提供了证据，表明苯妥英钠和普萘洛尔均不会因对心肌组织摄取洋地黄毒苷的任何显著干扰，而对洋地黄引起的心律失常产生抑制作用。
