Whalen J P, Krook L, MacIntyre I, Nunez E A
J Endocrinol. 1975 Aug;66(2):207-12. doi: 10.1677/joe.0.0660207.
After calcitonin injection, parathyroidectomy, or both, in young growing rats, broadening of the proximal femoral metaphysis with lack of normal concavity of the medial and lateral contours was observed radiographically. Histologically, this abnormal modelling was associated with retarded osteocytic osteolysis. Further manifestations of decelerated resorption included retention and extension of the chondroid core in the secondary spongiosa, retention of cartilage in the cortex and a large increase in the number of cementing lines.
在幼年生长大鼠中注射降钙素、进行甲状旁腺切除或两者都进行后，通过放射学观察到股骨近端干骺端变宽，内侧和外侧轮廓缺乏正常的凹陷。组织学上，这种异常重塑与骨细胞性骨溶解延迟有关。吸收减慢的进一步表现包括软骨样核心在次级海绵骨中的保留和延伸、皮质中软骨的保留以及黏合线数量的大幅增加。
