Stell P M
Proc R Soc Med. 1975 Feb;68(2):83-5. doi: 10.1177/003591577506800207.
It is suggested that the last major improvement in the surgical treatment of head and neck cancer was Crile's description of radical neck dissection in 1906, and that modifications of this procedure, including extended surgery, have made little or no difference to survival rates. It is hoped that some means may soon be found of identifying those patients with head and neck cancer who do badly--the majority. As a start, it is proposed that patients with an antral carcinoma and a gland in the neck, and patients with hypopharyngeal carcinoma and bilateral neck glands should not be treated by surgery. A retrospective analysis is made of matched pairs drawn from a personal series, one patient in each pair having had a prophylactic neck dissection, and one having been submitted to a policy of 'wait and see'. The survival rate for patients undergoing prophylactic neck dissection was worse than that of the wait and see group; this difference was statistically significant.
有人认为,头颈部癌外科治疗的最后一次重大进展是1906年克里尔对头颈根治性清扫术的描述,而该手术的改良,包括扩大手术范围,对生存率几乎没有影响。人们希望很快能找到一些方法来识别那些预后不良的头颈部癌患者——大多数患者。首先,建议对于患有上颌窦癌且颈部有淋巴结的患者以及患有下咽癌且双侧颈部有淋巴结的患者不应进行手术治疗。对个人病例系列中的配对病例进行了回顾性分析,每对病例中有一名患者接受了预防性颈部清扫术,另一名患者则采取了“观察等待”策略。接受预防性颈部清扫术的患者的生存率低于观察等待组;这种差异具有统计学意义。