Brismar J, Björklund A, Elner A, Eneroth C M
Neuroradiology. 1978;16:434-7. doi: 10.1007/BF00395325.
Regional intra-arterial drug administration has been advocated in order to reduce the risks of systemic complications in conjunction with systemic tumor chemotherapy. We have been using superselective angiographic techniques to administer the antitumor drug mitomycin C directly into the feeding arteries of the tumor in 15 patients with advanced malignant head and neck tumors. No complications were observed. In five patients the tumor decreased significantly in size, in four patients, tumor cell necrosis was found. A marked decrease in pain was reported by nine of the 15 patients.
为了在全身肿瘤化疗的同时降低全身并发症的风险，有人主张进行区域动脉内给药。我们一直在使用超选择性血管造影技术，将抗肿瘤药物丝裂霉素C直接注入15例晚期恶性头颈部肿瘤患者肿瘤的供血动脉。未观察到并发症。5例患者肿瘤大小显著减小，4例患者发现肿瘤细胞坏死。15例患者中有9例报告疼痛明显减轻。
