通过向哺乳期母鼠的幼崽单次腹腔注射一种3β-羟基-δ5-类固醇氧化还原酶抑制剂诱导母鼠肾上腺和卵巢增大。
Induced adrenal and ovarian enlargement in nursing mothers by a single mug injection to their pups of a 3beta-hydroxy-delta5-steroid oxidoreductase inhibitor.
作者信息
Shapiro B H, Goldman A S
出版信息
Proc Soc Exp Biol Med. 1975 Sep;149(4):896-9. doi: 10.3181/00379727-149-38922.
PMID:1166086
Abstract
Isoxazole-14C, a potent inhibitor of 3beta-hydroxy-delta5-steroid oxidoreductase, injected into nursing pups is naturally transferred to their mother where it is retained, for at least a month, in ng quantities in the adrenals and ovaries and results in adrenal, ovarian, preputial and pituitary enlargement.
摘要
异恶唑 -14C 是一种 3β - 羟基 -Δ5 - 类固醇氧化还原酶的强效抑制剂，将其注射到哺乳期幼崽体内后会自然转移至它们的母亲体内，在母亲的肾上腺和卵巢中以纳克量留存至少一个月，并导致肾上腺、卵巢、包皮和垂体增大。
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