Hyodo M, Sadamoto A, Murakami S
Department of Otolaryngology, Ehime University School of Medicine, Nagoya, Japan.
J Laryngol Otol. 2001 Oct;115(10):833-5. doi: 10.1258/0022215011909107.
Granular cell tumour is a rare neoplasm that can occur in various sites. This report describes a 48-year-old female with a malignant granular cell tumour originating from the cervical sympathetic nerve trunk, who presented with hyperaesthesia of the left shoulder. The tumour had a maximum diameter of 86 mm and involved adjacent tissues directly. Histopathologically, it showed considerable variation in the size and shape of nuclei, with occasional mitosis and an abundant granular cytoplasm. Immunohistochemically, the tumour reacted positively for S-100 protein and neuron-specific enolase, indicating its neural origin. Following total local excision of the lesion, the patient has been well without recurrence.
颗粒细胞瘤是一种可发生于多种部位的罕见肿瘤。本报告描述了一名48岁女性，患有起源于颈交感神经干的恶性颗粒细胞瘤，表现为左肩感觉过敏。肿瘤最大直径为86毫米，直接累及相邻组织。组织病理学检查显示，细胞核的大小和形状有很大差异，偶见有丝分裂，细胞质丰富且呈颗粒状。免疫组织化学检查显示，肿瘤对S-100蛋白和神经元特异性烯醇化酶呈阳性反应，表明其起源于神经。病变局部完全切除后，患者情况良好，无复发。
