Department of Pathology, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkey.
Department of Pathology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey.
Indian J Pathol Microbiol. 2020 Jul-Sep;63(3):478-480. doi: 10.4103/IJPM.IJPM_495_19.
A granular cell tumor (GCT) is a rare, usually benign soft tissue neoplasm that is commonly seen in the head and neck region. It is derived from the Schwann cells of the peripheral nerves. GCT is uncommon in children. 6-year-old girl was referred to our hospital for swelling over her left scapula, and a surgical excision was performed to remove the mass. Microscopically, the tumor was composed of cells with large granular cytoplasm and small oval to round nuclei. These cells stained positively for the following proteins: S-100, CD68, neuron-specific enolase, calretinin, and inhibin A. A GCT is usually benign, with a good prognosis, and less than 2% of the cases are reported to be malignant. It is worth noting that such tumors may arise in atypical locations and there is a possibility of malignancy.
颗粒细胞瘤（GCT）是一种罕见的、通常为良性的软组织肿瘤，常见于头颈部。它来源于周围神经的施万细胞。GCT 在儿童中较为少见。一位 6 岁女孩因左肩胛部肿胀就诊于我院，行手术切除肿块。显微镜下，肿瘤由具有大颗粒细胞质和小椭圆形至圆形核的细胞组成。这些细胞对以下蛋白呈阳性染色：S-100、CD68、神经元特异性烯醇化酶、钙视网膜蛋白和抑制素 A。GCT 通常为良性，预后良好，据报道仅有不到 2%的病例为恶性。值得注意的是，此类肿瘤可能发生在非典型部位，存在恶变的可能。
