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Total Synthesis of Apoptolidin: Part 2. Coupling of Key Building Blocks and Completion of the Synthesis We thank Dr. C. Khosla and Dr. Y. Hayakawa for generous gifts of apoptolidin, and Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), the Skaggs Institute for Chemical Biology, American Biosciences, a predoctoral fellowship from Boehringer Ingelheim (to Y.L.), a postdoctoral fellowship the George Hewitt Foundation (to K.C.F.), and grants from Abbott Laboratories, ArrayBiopharma, Bayer, Boehringer Ingelheim, DuPont, Glaxo, Hoffmann-LaRoche, Merck, Novartis, Pfizer, and Schering Plough.

作者信息

Nicolaou K. C., Li Yiwei, Fylaktakidou Konstantina C., Mitchell Helen J., Sugita Kazuyuki

机构信息

Department of Chemistry and The Skaggs Institute for Chemical Biology The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).

出版信息

Angew Chem Int Ed Engl. 2001 Oct 15;40(20):3854-3857.

PMID:11668554
Abstract
摘要

相似文献

1
Total Synthesis of Apoptolidin: Part 2. Coupling of Key Building Blocks and Completion of the Synthesis We thank Dr. C. Khosla and Dr. Y. Hayakawa for generous gifts of apoptolidin, and Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), the Skaggs Institute for Chemical Biology, American Biosciences, a predoctoral fellowship from Boehringer Ingelheim (to Y.L.), a postdoctoral fellowship the George Hewitt Foundation (to K.C.F.), and grants from Abbott Laboratories, ArrayBiopharma, Bayer, Boehringer Ingelheim, DuPont, Glaxo, Hoffmann-LaRoche, Merck, Novartis, Pfizer, and Schering Plough.
Angew Chem Int Ed Engl. 2001 Oct 15;40(20):3854-3857.
2
Total Synthesis of Apoptolidin: Part 1. Retrosynthetic Analysis and Construction of Building Blocks We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), the Skaggs Institute for Chemical Biology, American Biosciences, a pre-doctoral fellowship from Boehringer Ingelheim (Y.L.), a postdoctoral fellowship the George Hewitt Foundation (K.C.F.), and grants from Abbott Laboratories, ArrayBiopharma, Bayer, Boehringer Ingelheim, DuPont, Glaxo, Hoffmann-LaRoche, Merck, Novartis, Pfizer, and Schering Plough.凋亡诱导素的全合成：第1部分。逆合成分析与构建模块 我们分别感谢D. H. Huang博士和G. Siuzdak博士在核磁共振光谱和质谱分析方面提供的帮助。这项工作得到了美国国立卫生研究院、斯卡格斯化学生物学研究所、美国生物科学公司的资助，勃林格殷格翰公司提供的博士前奖学金（Y.L.）、乔治·休伊特基金会提供的博士后奖学金（K.C.F.），以及雅培实验室、Array生物制药公司、拜耳公司、勃林格殷格翰公司、杜邦公司、葛兰素公司、霍夫曼 - 罗氏公司、默克公司、诺华公司、辉瑞公司和先灵葆雅公司的资助。
Angew Chem Int Ed Engl. 2001 Oct 15;40(20):3849-3854.
3
Synthesis of the FGHI Ring System of Azaspiracid We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from Bristol-Myers Squibb (F.B.), postdoctoral fellowships from the Academy of Finland, the Ella and Georg Ehrnrooth Foundation, and the Tauno Tönning Foundation (all to P.M.P.), ArrayBiopharma (N.Z.), and Bayer AG (N.D.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.
Angew Chem Int Ed Engl. 2001 May 4;40(9):1573.
4
Synthesis of the FGHI Ring System of Azaspiracid We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from Bristol-Myers Squibb (F.B.), postdoctoral fellowships from the Academy of Finland, the Ella and Georg Ehrnrooth Foundation, and the Tauno Tönning Foundation (all to P.M.P.), ArrayBiopharma (N.Z.), and Bayer AG (N.D.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.azaspiracid的FGHI环系统的合成 我们分别感谢D. H. Huang博士和G. Siuzdak博士在核磁共振光谱和质谱分析方面提供的帮助。这项工作得到了斯卡格斯化学生物学研究所、美国国立卫生研究院、百时美施贵宝公司提供的博士前奖学金（给F.B.）、芬兰科学院、埃拉和格奥尔格·埃尔恩罗思基金会、陶诺·滕宁基金会（均给P.M.P.）、ArrayBiopharma公司（新西兰）、拜耳公司（给N.D.）的博士后奖学金，以及雅培公司、安进公司、ArrayBiopharma公司、勃林格殷格翰公司、葛兰素公司、霍夫曼-罗氏公司、杜邦公司、默克公司、诺华公司、辉瑞公司和先灵葆雅公司提供的资助。
Angew Chem Int Ed Engl. 2001 Apr 1;40(7):1262-1265.
5
New Synthetic Technology for the Construction of N-Containing Quinones and Derivatives Thereof: Total Synthesis of Epoxyquinomycin B We thank Dr. D. H. Huang, Dr. G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.B.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.含氮醌类及其衍生物构建的新合成技术：环氧喹诺霉素B的全合成 我们分别感谢D. H. Huang博士、G. Siuzdak博士和R. Chadha博士在核磁共振光谱、质谱和X射线晶体学分析方面提供的帮助。本研究得到了斯卡格斯化学生物学研究所、美国国立卫生研究院的资助，国家科学基金会为P.B.提供的博士前奖学金，以及雅培、安进、Array生物制药、勃林格殷格翰、葛兰素史克、霍夫曼-罗氏、杜邦、默克、诺华、辉瑞和先灵葆雅公司的资助。
Angew Chem Int Ed Engl. 2001 May 4;40(9):1573.
6
New Synthetic Technology for the Construction of N-Containing Quinones and Derivatives Thereof: Total Synthesis of Epoxyquinomycin B We thank Dr. D. H. Huang, Dr. G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.B.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.含氮醌类化合物及其衍生物构建的新型合成技术：环氧喹诺霉素B的全合成 我们分别感谢D. H. Huang博士、G. Siuzdak博士和R. Chadha博士在核磁共振光谱、质谱和X射线晶体学分析方面提供的帮助。本研究得到了斯卡格斯化学生物学研究所、美国国立卫生研究院的资助，国家科学基金会提供的博士前奖学金（P.B.），以及雅培、安进、Array生物制药、勃林格殷格翰、葛兰素史克、霍夫曼 - 罗氏、杜邦、默克、诺华、辉瑞和先灵葆雅公司的资助。
Angew Chem Int Ed Engl. 2001 Jan 5;40(1):207-210.
7
Synthesis of the ABCD Ring System of Azaspiracid We thank Drs. D. H. Huang and G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), The Skaggs Institute for Chemical Biology, a predoctoral fellowship from Bristol-Myers Squibb (to F.B.), postdoctoral fellowships from The Skaggs Institute for Research (to W.Q.), the Academy of Finland, the Ella and Georg Ehrnrooth Foundation and the Tauno Tönning Foundation (all to P.M.P.), and Bayer AG (to J.H.), as well as grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.azaspiracid的ABCD环系统的合成 我们分别感谢D. H. Huang博士和G. Siuzdak博士在核磁共振光谱和质谱分析方面提供的帮助。这项工作得到了美国国立卫生研究院、斯卡格斯化学生物学研究所、百时美施贵宝公司提供的博士前奖学金（给F.B.）、斯卡格斯研究所提供的博士后奖学金（给W.Q.）、芬兰科学院、埃拉和格奥尔格·埃尔恩罗思基金会以及陶诺·滕宁基金会（均给P.M.P.）、拜耳公司（给J.H.）的资助，以及雅培、安进、ArrayBiopharma、勃林格殷格翰、葛兰素史克、霍夫曼-罗氏、杜邦、默克、诺华、辉瑞和先灵葆雅公司提供的拨款。
Angew Chem Int Ed Engl. 2001 Nov 5;40(21):4068-4071.
8
Rapid Access to Complex Molecular Architectures via o-Azaquinones We thank Dr. D. H. Huang, G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. This work was supported financially by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.S.B), and grants from ArrayBiopharma, Pfizer, Glaxo, Merck, Schering Plough, Hoffmann-La Roche, Boehringer Ingelheim, DuPont, and Abbott Laboratories.
Angew Chem Int Ed Engl. 2001 Jun 1;40(11):2145-2149.
9
Mechanistic Studies of Periodinane-Mediated Reactions of Anilides and Related Systems Professors M. G. Finn, A. Eschenmoser, and M. E. Newcomb are gratefully acknowledged for valuable discussions and suggestions. We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. We would also like to thank Dr. G. Vasilikogiannakis for helpful discussions and an anonymous referee for critical suggestions. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.B.), postdoctoral fellowships from ArrayBiopharma (N.Z.) and Bayer AG (R.K.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.高碘烷介导的酰苯胺及相关体系反应的机理研究 衷心感谢M. G. 芬恩教授、A. 埃申莫泽教授和M. E. 纽科姆教授进行的宝贵讨论并提出建议。我们分别感谢D. H. 黄博士和G. 苏兹达克博士在核磁共振光谱分析和质谱分析方面提供的帮助。我们还要感谢G. 瓦西利科贾纳基斯博士进行的有益讨论，以及一位匿名审稿人提出的批判性建议。这项工作得到了斯卡格斯化学生物学研究所、美国国立卫生研究院、美国国家科学基金会提供的博士前奖学金（P.B.）、ArrayBiopharma公司（N.Z.）和拜耳公司（R.K.）提供的博士后奖学金，以及雅培公司、安进公司、ArrayBiopharma公司、勃林格殷格翰公司、葛兰素公司、霍夫曼 - 罗氏公司、杜邦公司、默克公司、诺华公司、辉瑞公司和先灵葆雅公司提供的资助。
Angew Chem Int Ed Engl. 2001 Jan 5;40(1):202-206.
10
Total Synthesis of Hybocarpone We thank Dr. D. H. Huang, Dr. G. Siuzdak and Dr. I. Ioannou for NMR spectroscopic, mass spectrometric and computational assistance, respectively. Financial support for this work was provided by the Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Novartis, Pfizer, CaPCURE, and Schering Plough.
Angew Chem Int Ed Engl. 2001 Feb 16;40(4):761-763.

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J Org Chem. 2008 Jul 4;73(13):4949-55. doi: 10.1021/jo800545r. Epub 2008 Jun 11.