非诺贝特对嘌呤碱和氧嘌呤醇血浆浓度及尿排泄的影响。
Effect of fenofibrate on plasma concentration and urinary excretion of purine bases and oxypurinol.
作者信息
Yamamoto T, Moriwaki Y, Takahashi S, Tsutsumi Z, Hada T
机构信息
Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
出版信息
J Rheumatol. 2001 Oct;28(10):2294-7.
OBJECTIVE
To investigate whether fenofibrate increases the clearance of purine bases (hypoxanthine, xanthine, uric acid) and oxypurinol.
METHODS
We administered fenofibrate (150 mg) 3 times a day for 3 days, and then allopurinol (300 mg) 4 h after the last administration of fenofibrate, to 5 healthy subjects. Ten hours later, a clearance study was done.
RESULTS
Following 3 day administration of fenofibrate, fractional clearance of xanthine, uric acid, and oxypurinol increased by 41% (p < 0.05), 101% (p < 0.01), and 51% (p < 0.01), respectively, compared to baseline values, while the respective plasma concentrations decreased by 46% (p < 0.05), 46% (p < 0.05), and 19% (p < 0.05).
CONCLUSION
Our results suggest that fenofibrate, fenofibric acid, or fenofibrate derivatives can increase fractional clearance of xanthine, uric acid, and oxypurinol by acting on their common renal pathways. It is suggested that the hypouricemic effect of combination therapy using allopurinol and fenofibrate may be less than additive.
目的
研究非诺贝特是否能增加嘌呤碱（次黄嘌呤、黄嘌呤、尿酸）和氧嘌呤醇的清除率。
方法
我们对5名健康受试者每天3次给予非诺贝特（150毫克），共给药3天，然后在最后一次给予非诺贝特4小时后给予别嘌醇（300毫克）。10小时后，进行清除率研究。
结果
与基线值相比，连续3天给予非诺贝特后，黄嘌呤、尿酸和氧嘌呤醇的分数清除率分别提高了41%（p<0.05）、101%（p<0.01）和51%（p<0.01），而各自的血浆浓度分别降低了46%（p<0.05）、46%（p<0.05）和19%（p<0.05）。
结论
我们的结果表明，非诺贝特、非诺贝酸或非诺贝特衍生物可通过作用于其共同的肾脏途径增加黄嘌呤、尿酸和氧嘌呤醇的分数清除率。提示别嘌醇与非诺贝特联合治疗的降尿酸作用可能小于相加作用。
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