胰高血糖素对氧嘌呤醇和嘌呤碱肾脏排泄的影响。
Effect of glucagon on renal excretion of oxypurinol and purine bases.
作者信息
Yamamoto T, Moriwaki Y, Takahashi S, Tsutsumi Z, Hiroishi K, Yamakita J, Nakano T, Higashino K
机构信息
Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
出版信息
J Rheumatol. 1997 Apr;24(4):708-13.
OBJECTIVE
To investigate whether glucagon increases the urinary excretion of oxypurinol and purine bases.
METHODS
We administered 1 mg glucagon intravenously to 5 healthy subjects taking 300 mg allopurinol orally, and determined plasma concentrations and urinary excretion of oxypurinol and purine bases.
RESULTS
Glucagon increased the urinary excretion and fractional clearances of uric acid, xanthine, and oxypurinol, together with an increase in creatinine clearance, while it decreased plasma concentrations of xanthine and hypoxanthine.
CONCLUSION
Glucagon-induced increases in urinary excretion of uric acid, xanthine, and oxypurinol were attributable to increases in the fractional clearances of uric acid, xanthine, and oxypurinol in addition to an increase in glomerular filtration rate. It is suggested that glucagon affects the renal common transport pathway of uric acid, xanthine, and oxypurinol by stimulating the release of a liver derived renal vasodilator.
目的
研究胰高血糖素是否会增加氧嘌呤醇和嘌呤碱的尿排泄量。
方法
我们对5名口服300毫克别嘌醇的健康受试者静脉注射1毫克胰高血糖素，并测定氧嘌呤醇和嘌呤碱的血浆浓度及尿排泄量。
结果
胰高血糖素增加了尿酸、黄嘌呤和氧嘌呤醇的尿排泄量及分数清除率，同时肌酐清除率增加，而黄嘌呤和次黄嘌呤的血浆浓度降低。
结论
胰高血糖素引起的尿酸、黄嘌呤和氧嘌呤醇尿排泄量增加，除肾小球滤过率增加外，还归因于尿酸、黄嘌呤和氧嘌呤醇分数清除率的增加。提示胰高血糖素通过刺激肝脏来源的肾血管舒张剂释放，影响尿酸、黄嘌呤和氧嘌呤醇的肾脏共同转运途径。
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