Tidow-Kebritchi S, Mobarhan S
Loyola University Medical Center, Maywood, IL 60153, USA.
Nutr Rev. 2001 Oct;59(10):335-8. doi: 10.1111/j.1753-4887.2001.tb06958.x.
Animal, tissue culture, and human studies have evaluated the effects of fish oil supplementation in patients with rheumatoid arthritis (RA) over the last two decades. These studies have clearly shown potentially beneficial changes in cytokine and eicosanoid metabolism. The overall clinical improvement, however, has been only moderate. European clinical trials have shown significant pain reduction in patients with RA treated with vitamin E. A recent animal study in RA-prone mice evaluated the effects of vitamin E in addition to omega-3 and omega-6 fatty acids on cytokine and eicosanoid production. The authors suggest that vitamin E might have an additional positive effect on autoimmune disease by decreasing proinflammatory cytokines and lipid mediators. Is this information ultimately important in terms of dietary advice for patients with RA? Are further clinical trials indicated? The following article will present a brief critical review.
在过去二十年中，动物、组织培养和人体研究评估了补充鱼油对类风湿性关节炎（RA）患者的影响。这些研究清楚地表明，细胞因子和类花生酸代谢发生了潜在的有益变化。然而，总体临床改善程度仅为中等。欧洲的临床试验表明，接受维生素E治疗的RA患者疼痛明显减轻。最近一项针对易患RA小鼠的动物研究评估了除ω-3和ω-6脂肪酸外，维生素E对细胞因子和类花生酸生成的影响。作者认为，维生素E可能通过减少促炎细胞因子和脂质介质对自身免疫性疾病产生额外的积极作用。就RA患者的饮食建议而言，这些信息最终是否重要？是否需要进一步的临床试验？以下文章将进行简要的批判性综述。
