Tabara H, Kohno H, Dhar D K, Kotoh T, Yoshimura H, Masunaga R, Tachibana M, Kubota H, Nagasue N
Second Department of Surgery, Shimane Medical University, Izumo, Japan.
Acta Oncol. 2001;40(5):622-8. doi: 10.1080/028418601750444178.
Details of concurrent expression of angiogenic growth factors (AGFs) and microvessel density (MVD) in human colorectal adenomas and carcinomas remain obscure. Eighty lesions, 20 each from colorectal adenoma, Tis, T1 and T2 cancers were evaluated immunohistochemically for basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), thymidine phosphorylase (dThdPase) and MVD. MVD (p = 0.0001) and bFGF expression (p = 0.0001) increased in the order of adenoma, Tis, T1 and T2 cancers. VEGF expression was same in adenomas and cancers while dThdPase was weak in adenomas but strongly expressed in invasive carcinomas ( > T1). MVD had positive correlation with tumour size in small (< or = 4 cm) colorectal cancers. Concurrent expression of AGFs was noticed in invasive carcinomas. bFGF seems to be the strongest among the three AGFs expressed during colorectal carcinogenesis and had a significant correlation with tumour MVD. Concurrent expression of multiple AGFs is a crucial step in the transition from non-invasive to invasive carcinoma.
血管生成生长因子（AGFs）与人结肠直肠腺瘤和癌中微血管密度（MVD）的同时表达细节仍不清楚。对80个病变进行了免疫组织化学评估，其中20个来自结肠直肠腺瘤，20个来自Tis期癌，20个来自T1期癌，20个来自T2期癌，检测碱性成纤维细胞生长因子（bFGF）、血管内皮生长因子（VEGF）、胸苷磷酸化酶（dThdPase）和MVD。MVD（p = 0.0001）和bFGF表达（p = 0.0001）按照腺瘤、Tis期癌、T1期癌和T2期癌的顺序增加。腺瘤和癌中的VEGF表达相同，而dThdPase在腺瘤中表达较弱，但在浸润性癌（> T1）中强烈表达。在小的（≤4 cm）结肠直肠癌中，MVD与肿瘤大小呈正相关。在浸润性癌中观察到AGFs的同时表达。在结肠直肠癌发生过程中表达的三种AGFs中，bFGF似乎是最强的，并且与肿瘤MVD有显著相关性。多种AGFs的同时表达是从非浸润性癌向浸润性癌转变的关键步骤。
