von Sydow K, Lieb R, Pfister H, Höfler M, Sonntag H, Wittchen H U
Max Planck Institute of Psychiatry, Clinical Psychology and Epidemiology, Kraepelinstrasse 2, 80804 Munich, Germany.
Drug Alcohol Depend. 2001 Nov 1;64(3):347-61. doi: 10.1016/s0376-8716(01)00137-5.
To determine incidence and patterns of natural course of cannabis use and disorders as well as cohort effects in a community sample of adolescents and young adults.
Cumulative incidence and patterns of cannabis use and disorders were examined in a prospective longitudinal design (mean follow-up period=42 months) in a representative sample (N=2446) aged 14-24 years at the outset of the study. Patterns of cannabis use, abuse and dependence (DSM-IV) were assessed with the Composite International Diagnostic Interview (M-CIDI).
(1) Cumulative lifetime incidence for cannabis use (at second follow-up): 47%; 5.5% for cannabis abuse, 2.2% for dependence. (2) Men used and abused cannabis more often than women. (3) The majority of the older participants (18-24 years at baseline) had reduced their cannabis use at follow-up, while younger participants (14-17 years at baseline) more often had increased their use and developed abuse or dependence. (4) The younger birth cohort (1977-1981) tended to start earlier with substance (ab)use compared to the older birth cohort (1970-1977). (5) Cannabis use was associated with increasing rates of concomitant use of other licit and illicit drugs.
Cannabis use is widespread in our sample, but the probability of developing cannabis abuse or dependence is relatively low (8%). The natural course of cannabis use is quite variable: about half of all cannabis users stopped their use spontaneously in their twenties, others report occasional or more frequent use of cannabis.
确定大麻使用及相关障碍的自然病程发生率和模式,以及青少年和青年社区样本中的队列效应。
在一项前瞻性纵向研究设计(平均随访期 = 42个月)中,对研究开始时年龄在14 - 24岁的代表性样本(N = 2446)进行大麻使用及相关障碍的累积发生率和模式检查。使用综合国际诊断访谈(M - CIDI)评估大麻使用、滥用和依赖(DSM - IV)模式。
(1)大麻使用的累积终生发生率(在第二次随访时):47%;大麻滥用为5.5%,依赖为2.2%。(2)男性使用和滥用大麻的频率高于女性。(3)大多数年龄较大的参与者(基线时18 - 24岁)在随访时减少了大麻使用,而年龄较小的参与者(基线时14 - 17岁)更常增加使用并发展为滥用或依赖。(4)与年龄较大的出生队列(1970 - 1977年)相比,年龄较小的出生队列(1977 - 1981年)往往更早开始使用(滥用)物质。(5)大麻使用与其他合法和非法药物同时使用的比率增加有关。
在我们的样本中,大麻使用很普遍,但发展为大麻滥用或依赖的可能性相对较低(8%)。大麻使用的自然病程差异很大:所有大麻使用者中约有一半在二十多岁时自行停止使用,其他人报告偶尔或更频繁地使用大麻。