Alcohol Research Group, Public Health Institute, CA, United States.
Addict Behav. 2024 May;152:107957. doi: 10.1016/j.addbeh.2024.107957. Epub 2024 Jan 17.
Previous studies have only investigated the short-term association of recent cannabis use with cannabis-related problems, without accounting for the onset, duration, and variations in frequency of use in the life-course.
We obtained data from the Washington panel survey during 2014-2016. We constructed accumulated lifetime exposure to cannabis use, heavy drinking (5+ drinks on one occasion), and cigarette pack-years from age of onset based on a series of decades-based questions on cannabis use and heavy drinking, and tobacco use history. We used Generalized Estimating Equation with Poisson distribution to investigate the association between accumulated cannabis use and the past-6-month CUDIT score. We adjusted for accumulated heavy drinking and cigarette pack-years, substance co-use variables, demographics, and applied survey weights.
We found strong and statistically significant correlations for the lifetime measures across the four panel surveys, indicating that the life-course measures of cannabis use and heavy drinking were largely reliable. We found a statistically significant relationship between the lifetime accumulated exposure to cannabis and CUDIT. The results were robust to the inconsistencies in reported frequencies and onset age across panel surveys.
This study established the relationship between lifetime exposure to cannabis and cannabis-related problems in a representative sample of drinkers and marijuana users in Washington state. We have also provided test-retest validity and question details for the decades-based cannabis and heavy drinking measures to facilitate their use in future studies of cannabis and alcohol-related outcomes.
以往的研究仅调查了近期大麻使用与大麻相关问题的短期关联，而没有考虑一生中大麻使用的发病、持续时间和频率变化。
我们从 2014-2016 年的华盛顿小组调查中获取了数据。我们根据一系列基于几十年的大麻使用和重度饮酒问题以及吸烟史的问题，基于发病年龄构建了累积一生的大麻使用、重度饮酒（一次性 5 杯以上）和吸烟包年数的累积暴露。我们使用广义估计方程和泊松分布来研究累积大麻使用与过去 6 个月 CUDIT 评分之间的关联。我们调整了累积重度饮酒和吸烟包年数、物质共同使用变量、人口统计学因素，并应用了调查权重。
我们发现四个小组调查的终生测量值之间存在很强的统计学显著相关性，这表明大麻使用和重度饮酒的终生测量值在很大程度上是可靠的。我们发现大麻终生累积暴露与 CUDIT 之间存在统计学显著关系。结果在跨小组调查中报告的频率和发病年龄不一致的情况下仍然稳健。
本研究在华盛顿州饮酒者和大麻使用者的代表性样本中确立了终生暴露于大麻与大麻相关问题之间的关系。我们还为基于几十年的大麻和重度饮酒测量提供了重测信度和问题细节，以促进它们在未来的大麻和酒精相关结果研究中的使用。
