原发性进行性多发性硬化症患者中干燥综合征的患病率。
The prevalence of Sjögren syndrome in patients with primary progressive multiple sclerosis.
作者信息
de Seze J, Devos D, Castelnovo G, Labauge P, Dubucquoi S, Stojkovic T, Ferriby D, Vermersch P
机构信息
Department of Neurology, CHRU de Lille, France.
出版信息
Neurology. 2001 Oct 23;57(8):1359-63. doi: 10.1212/wnl.57.8.1359.
OBJECTIVE
To assess the prevalence of Sjögren syndrome (SS) in patients with primary progressive MS (PPMS).
BACKGROUND
SS may be considered in the differential diagnosis of MS. Age at onset and clinical presentation are similar in SS and PPMS. However, occurrence of SS in definite cases of PPMS has been recently reported.
METHODS
Proposed clinical and laboratory diagnostic criteria for SS were systematically assessed in 60 consecutive patients with PPMS. The authors questioned all patients about xerophthalmia and xerostomia, biopsied minor salivary glands, and performed a Schirmer test, a salivary gland scintigraphy, and anti-Ro (SSa) and anti-La (SSb) serologies.
RESULTS
Ten patients (16.6%) met four or more criteria for SS. This prevalence is higher than in the general population (1 to 5%) and implies that SS can mimic PPMS.
CONCLUSIONS
The authors propose that SS should be screened for systematically in patients with PPMS.
目的
评估原发性进展型多发性硬化（PPMS）患者中干燥综合征（SS）的患病率。
背景
在多发性硬化的鉴别诊断中可能会考虑干燥综合征。干燥综合征和原发性进展型多发性硬化的发病年龄及临床表现相似。然而，最近有报道称在确诊的原发性进展型多发性硬化病例中出现了干燥综合征。
方法
对60例连续的原发性进展型多发性硬化患者系统评估了提议的干燥综合征临床和实验室诊断标准。作者询问了所有患者有关干眼症和口干症的情况，对小唾液腺进行活检，并进行了Schirmer试验、唾液腺闪烁扫描以及抗Ro（SSa）和抗La（SSb）血清学检测。
结果
10例患者（16.6%）符合四项或更多干燥综合征标准。这一患病率高于普通人群（1%至5%），提示干燥综合征可能会模仿原发性进展型多发性硬化。
结论
作者建议应对原发性进展型多发性硬化患者系统筛查干燥综合征。
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