Katritzky Alan R., Cui Xi-Lin, Yang Baozhen, Steel Peter J.
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, and Department of Chemistry, University of Canterbury, Christchurch, New Zealand.
J Org Chem. 1999 Mar 19;64(6):1979-1985. doi: 10.1021/jo9821426.
Benzotriazole, 2,5-dimethoxytetrahydrofuran, and (S)-phenylglycinol in one step gave 80% of (3S, 5R,7aR)-5-(benzotriazol-1-yl)-3-phenyl-[2,1-b]oxazolopyrrolidine (6), whose crystal structure was confirmed by X-ray crystallography. Novel chiral pyrrolidine synthon 6 reacts with organosilicon (allyltrimethylsilanes and vinyloxytrimethylsilanes), organophosphorus, organozinc, and Grignard reagents to afford chiral 2-substituted and 2,5-disubstituted pyrrolidines.
苯并三唑、2,5 - 二甲氧基四氢呋喃和(S)-苯甘醇一步反应生成80%的(3S, 5R,7aR)-5-(苯并三唑 - 1 - 基)-3 - 苯基 - [2,1 - b]恶唑并吡咯烷(6)，其晶体结构通过X射线晶体学得到证实。新型手性吡咯烷合成子6与有机硅（烯丙基三甲基硅烷和乙烯氧基三甲基硅烷）、有机磷、有机锌和格氏试剂反应，得到手性2 - 取代和2,5 - 二取代吡咯烷。
