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人类线粒体DNA会发生重组吗?

Does human mtDNA recombine?

作者信息

Eyre-Walker A, Awadalla P

机构信息

Centre for the Study of Evolution & School of Biological Sciences, University of Sussex, Brighton, BNI 9QG, United Kingdom.

出版信息

J Mol Evol. 2001 Oct-Nov;53(4-5):430-5. doi: 10.1007/s002390010232.

DOI:10.1007/s002390010232
PMID:11675602
Abstract

In this article we review the evidence for and against recombination in human mtDNA. If recombination occurs, there needs to be a route by which genetic material can incorporate itself into the mitochondrial genome, and hence between mitochondrial lineages. We review the evidence for possible routes and then review the current state of the population genetic evidence for recombination. We conclude that there is no firmly established route by which recombination can occur, and that while some of the population genetic evidence is suggestive of recombination, it is far from conclusive.

摘要

在本文中,我们回顾了支持和反对人类线粒体DNA发生重组的证据。如果发生重组,那么遗传物质需要有一条途径将自身整合到线粒体基因组中,进而在线粒体谱系之间整合。我们回顾了可能途径的证据,然后审视了群体遗传学中关于重组证据的当前状况。我们得出结论,目前尚无确凿的重组发生途径,并且虽然一些群体遗传学证据暗示了重组的存在,但远非结论性的。

相似文献

1
Does human mtDNA recombine?人类线粒体DNA会发生重组吗?
J Mol Evol. 2001 Oct-Nov;53(4-5):430-5. doi: 10.1007/s002390010232.
2
Do mitochondria recombine in humans?人类的线粒体是否会发生重组?
Philos Trans R Soc Lond B Biol Sci. 2000 Nov 29;355(1403):1573-80. doi: 10.1098/rstb.2000.0718.
3
Mitochondrial DNA and human evolution.线粒体DNA与人类进化。
Annu Rev Genomics Hum Genet. 2005;6:165-83. doi: 10.1146/annurev.genom.6.080604.162249.
4
Questioning evidence for recombination in human mitochondrial DNA.对人类线粒体DNA中重组证据的质疑。
Science. 2000 Jun 16;288(5473):1931.
5
Can indirect tests detect a known recombination event in human mtDNA?间接测试能否检测出人类线粒体DNA中已知的重组事件?
Mol Biol Evol. 2009 Jul;26(7):1435-9. doi: 10.1093/molbev/msp073. Epub 2009 Apr 15.
6
Questioning evidence for recombination in human mitochondrial DNA.对人类线粒体DNA中重组证据的质疑。
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7
[Nuclear mitochondrial pseudogenes].[核线粒体假基因]
Mol Biol (Mosk). 2010 May-Jun;44(3):405-17.
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Recombination or mutation rate heterogeneity? Implications for Mitochondrial Eve.重组率还是突变率的异质性?对线粒体夏娃的影响。
Trends Genet. 2003 Feb;19(2):84-90. doi: 10.1016/S0168-9525(02)00048-3.
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Divergence, hybridization, and recombination in the mitochondrial genome of the human pathogenic yeast Cryptococcus gattii.人类致病酵母新型隐球菌线粒体基因组中的分歧、杂交和重组。
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Multiple nuclear pseudogenes of mitochondrial DNA exist in the canine genome.犬类基因组中存在线粒体DNA的多个核假基因。
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