Takaishi Y, Miki T, Nishizawa Y, Morii H
Takaishi Dental Clinic, Himeji, Japan.
J Int Med Res. 2001 Jul-Aug;29(4):355-65. doi: 10.1177/147323000102900413.
Etidronate 200 mg daily was administered to four female patients with periodontitis and resultant alveolar pyorrhoea for periods of 2 weeks, followed by off-periods of 10 weeks or more, for 2-3 years. The macroscopic appearance of gingival mobility of the teeth, depth of periodontal pockets, and X-ray findings of alveolar bones improved markedly during this time. The effects were first observed after 6-12 months of treatment. These findings indicate that bisphosphonates may be effective in the treatment of periodontitis and resultant alveolar pyorrhoea. The effect may be mediated by the inhibitory action on bone resorption and the anti-inflammatory action of etidronate. Concomitant conventional dental management is also required.
对四名患有牙周炎并伴有牙槽脓溢的女性患者，每日给予200毫克依替膦酸，治疗2周，随后停药10周或更长时间，持续2至3年。在此期间，牙齿牙龈松动的宏观表现、牙周袋深度以及牙槽骨的X线检查结果均有明显改善。治疗6至12个月后首次观察到疗效。这些发现表明，双膦酸盐可能对牙周炎及由此导致的牙槽脓溢有效。这种效果可能是由依替膦酸对骨吸收的抑制作用和抗炎作用介导的。同时也需要进行常规的牙科治疗。
