Qu P, Ding Y, Xia D, Wang H, Tian X
Cardiovascular Department of Internal Medicine, the Second Affiliated Hospital of Dalian Medical University, China.
Hypertens Res. 2001 Sep;24(5):601-4. doi: 10.1291/hypres.24.601.
To evaluate the alteration of cardiac function in hypertensive patients with different left ventricular geometric patterns. Echocardiography was used to study left ventricular geometry and cardiac diastolic function in 117 cases of essential hypertension, with 45 normal cases as controls. Echocardiographic date were used to calculated the left ventricular mass index (LVMI) and relative wall thickness (RWT), which values in turn were used to divide the subjects into four groups. The left atrial dimension of the group, with the exception of these hypertensives who showed normal geometry, was larger than that of the control group. The damage of peak of E velocity, peak of A velocity, E/A and the slope between the E and F points (E to F slope) were greater than in hypertension than in the control group. The concentric hypertrophy group and eccentric hypertrophy group suffered more serious damage of left ventricular diastolic function than the concentric remodeling group, and damage of left ventricular diastolic function in the concentric remodeling group was greater than that in the normal geometry group. The degree of cardiac diastolic function damage differed among patients with different left ventricular geometric patterns, when the cardiac structure was changed, the degree of cardiac diastolic function damage increased.
评估不同左心室几何形态的高血压患者的心功能改变。采用超声心动图研究117例原发性高血压患者的左心室几何形态及心脏舒张功能,并以45例正常者作为对照。利用超声心动图数据计算左心室质量指数(LVMI)和相对室壁厚度(RWT),并依次根据这些值将研究对象分为四组。除几何形态正常的高血压患者外,该组患者的左心房内径均大于对照组。高血压患者E峰速度、A峰速度、E/A及E点与F点之间的斜率(E至F斜率)的损害程度均高于对照组。与向心性重构组相比,向心性肥厚组和离心性肥厚组的左心室舒张功能损害更严重,且向心性重构组的左心室舒张功能损害程度大于几何形态正常组。不同左心室几何形态的患者心脏舒张功能损害程度不同,心脏结构改变时,心脏舒张功能损害程度增加。