包裹于聚（d，l-丙交酯-共-乙交酯）微球中的抗体诱导的独特型级联反应的抗肿瘤作用

Antitumor effect of the idiotypic cascade induced by an antibody encapsulated in poly(d,l-lactide-co-glycolide) microspheres.

作者信息

Ma J, Luo D, Qi W, Cao L

机构信息

National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Panjiayuan, Beijing, China 100021.

出版信息

Jpn J Cancer Res. 2001 Oct;92(10):1110-5. doi: 10.1111/j.1349-7006.2001.tb01066.x.

DOI:10.1111/j.1349-7006.2001.tb01066.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5926615/

Abstract

A major difficulty encountered during development of antibody vaccines is their weak immunogenicity. In this study, a monoclonal antibody CS20.5 to human breast cancer antigen CA15.3 was coencapsulated in poly(d,l-lactide-co-glycolide) microspheres with monophosphoryl lipid A. The antitumor effect of this formulation was investigated in a murine model. The induced Ab2 biologically mimics antigen as it competed with CA15.3 for the same idiotope on Ab1. Ab3 induction was also observed. After five sequential administrations of encapsulated antibody, mice showed statistically significant tumor regression. These results indicate that this formulation may serve as a potential treatment for breast cancer.

摘要

抗体疫苗研发过程中遇到的一个主要困难是其免疫原性较弱。在本研究中，将一种针对人乳腺癌抗原CA15.3的单克隆抗体CS20.5与单磷酰脂质A共同包裹于聚（d，l-丙交酯-共-乙交酯）微球中。在小鼠模型中研究了该制剂的抗肿瘤效果。诱导产生的Ab2在与CA15.3竞争Ab1上的相同独特型时，在生物学上模拟抗原。还观察到了Ab3的诱导。在连续五次给予包裹抗体后，小鼠的肿瘤出现了具有统计学意义的消退。这些结果表明，该制剂可能成为乳腺癌的一种潜在治疗方法。

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