Lebrun C
Service de Neurologie, Hôpital Pasteur, 30, voie Romaine, BP 69, 06002 Nice Cedex, France.
Rev Neurol (Paris). 2001 Sep;157(8-9 Pt 1):761-7.
Magnetic resonance imaging has revolutionized management of patients with multiple sclerosis. This tool provides information on a dynamic process never visualized before, optimizing diagnostic capacities and formalizing the course of the lesion load. Follow-in clinical assessment and performance testing, MRI constitutes a second line tool for following the course of patients with multiple sclerosis in phase II and III trials. We reviewed the correlations between the radiological and clinical findings and the methodology of published trials on beta interferons in remitting, secondarily progressive and early onset multiple sclerosis.
磁共振成像已经彻底改变了多发性硬化症患者的治疗方式。该工具提供了有关一个以前从未可视化的动态过程的信息，优化了诊断能力并规范了病灶负荷的发展过程。在后续的临床评估和性能测试中，磁共振成像构成了在II期和III期试验中追踪多发性硬化症患者病程的二线工具。我们回顾了在缓解型、继发进展型和早发型多发性硬化症中，放射学和临床发现之间的相关性以及已发表的关于β干扰素试验的方法学。
