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自闭症与小脑。MRI的一项异常发现。

Autism and cerebellum. An unusual finding with MRI.

作者信息

Muratori F, Cesari A, Casella C

机构信息

Institute of Child Neuropsychiatry, IRCCS Stella Maris, University of Pisa, Pisa, Italy.

出版信息

Panminerva Med. 2001 Dec;43(4):311-5.

Abstract

In recent years neuroimaging techniques have shown in young autistic children morphological disorders of the brainstem and cerebellum. After a review of the literature the authors present a three-year-old child, with a pervasive developmental disorder (autistic type) whose MRI shows an unusual finding in the right cerebellar hemisphere. The achieved levels in many developmental areas (linguistic, cognitive, relational, communicative) have been referred too. This developmental description represents additional information to the research about possible correlations between autistic symptoms and neuroanatomic abnormalities. The focus is about the role of neocerebellum in complex processes such as joint attention, shift attention, cognitive and linguistic functions which are probably involved in pathogenesis of autistic disorder. The presence of such inabilities in a case with cerebellar hemisphere abnormalities, without vermis compromission, could suggest that in autism exist deficits in more complex connections between neocerebellum and others regions of the brain.

摘要

近年来,神经影像学技术显示,年幼的自闭症儿童存在脑干和小脑的形态学紊乱。在回顾文献之后,作者呈现了一名三岁的广泛性发育障碍(自闭症类型)患儿,其脑部磁共振成像(MRI)显示右侧小脑半球有异常发现。文中还提及了该患儿在多个发育领域(语言、认知、社交、沟通)所达到的水平。这一发育描述为有关自闭症症状与神经解剖学异常之间可能存在的关联研究提供了更多信息。重点在于新小脑在诸如共同注意、注意力转移、认知和语言功能等复杂过程中的作用,而这些功能可能与自闭症谱系障碍的发病机制有关。在一例小脑半球异常但蚓部未受影响的病例中出现此类功能缺陷,可能表明自闭症患者新小脑与大脑其他区域之间存在更为复杂的连接缺陷。

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