Ikeda K, Yokoyama M, Tomita K, Tanaka S
Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Japan.
Hand Surg. 2001 Jul;6(1):29-35. doi: 10.1142/s0218810401000400.
The purpose of this study is to clarify the vulnerability of the gradually elongated peripheral nerve. Rabbit's sciatic nerves were gradually elongated to 30 mm at the rate of 2.0 mm/day and 4.0 mm/day. Immediately after elongation, the sciatic nerve was exposed and compressed for 30 minutes at various forces, 15, 30 and 60 g/0.1 cm(2). Immediately after elongation and compression, 2, 4 and 8 weeks after compression, each group was electrophysiologically and histologically estimated--15 g/0.1 cm(2) caused no damage to the control group, neurapraxia to the 2.0 mm/day group, and axonotmesis to the 4.0 mm/day group; 30 g/0.1 cm(2) caused neurapraxia to the control group and axonotmesis to the 2.0 mm/day group; 60 g/0.1 cm(2) caused axonotmesis to the control group and slowly recovered axonotmesis to the 2.0 mm/day group. This study shows that though mild compression, does not cause nerve injury to the intact nerve, it can sometimes cause severe damage to the gradual elongated nerve.
本研究的目的是阐明逐渐延长的周围神经的易损性。将兔的坐骨神经以每天2.0毫米和4.0毫米的速度逐渐延长至30毫米。延长后立即暴露坐骨神经，并以15、30和60克/0.1平方厘米的不同压力压缩30分钟。在延长和压缩后立即、压缩后2周、4周和8周，对每组进行电生理和组织学评估——15克/0.1平方厘米对对照组无损伤，对每天延长2.0毫米的组造成神经失用，对每天延长4.0毫米的组造成轴突断裂；30克/0.1平方厘米对对照组造成神经失用，对每天延长2.0毫米的组造成轴突断裂；60克/0.1平方厘米对对照组造成轴突断裂，对每天延长2.0毫米的组造成缓慢恢复的轴突断裂。本研究表明，尽管轻度压迫对完整神经不会造成神经损伤，但有时会对逐渐延长的神经造成严重损伤。
