Ikeda K, Tomita K, Tanaka S
Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.
Hand Surg. 2000 Jul;5(1):41-7. doi: 10.1142/s0218810400000028.
The purpose of this study was to clarify how fast the peripheral nerve can be elongated gradually without inducing nerve conduction block, and to assess whether the damage to the peripheral nerve is reversible. Rabbit femur was gradually elongated to 30 mm at the rate of 0.8 mm/day, 2.0 mm/day, and 4.0 mm/day to stretch the sciatic nerve. Immediately after and eight weeks after elongation, each group was estimated. Elongation of the Ranvier's node, which was likely the cause of conduction block, was observed and its severity increased with elongation speed. There was no Wallerian degeneration even when conduction block was complete. There was little damage to the sciatic nerve in the group of 0.8 mm/day. Damage in the group of 2.0 mm/day immediately after elongation had a tendency to recover by eight weeks, but there was no such tendency in the group of 4.0 mm/day.
本研究的目的是阐明外周神经在不引起神经传导阻滞的情况下能以多快的速度逐渐延长，并评估外周神经损伤是否可逆。将兔股骨分别以0.8毫米/天、2.0毫米/天和4.0毫米/天的速度逐渐延长30毫米，以拉伸坐骨神经。延长后立即及延长八周后对每组进行评估。观察到郎飞结的延长，这可能是传导阻滞的原因，其严重程度随延长速度增加。即使传导阻滞完全，也没有发生华勒氏变性。在0.8毫米/天的组中，坐骨神经几乎没有损伤。在2.0毫米/天的组中，延长后立即出现的损伤在八周时有恢复的趋势，但在4.0毫米/天的组中没有这种趋势。
