Zupan I P, Varl J, Kovac D, Cernelc P, Mlakar U, Andoljsek D, Pretnar J, Zver S, Modic M
Department of Haematology, University Medical Centre, Ljubljana, Slovenia.
Pflugers Arch. 2001;442(6 Suppl 1):R202-3. doi: 10.1007/s004240100025.
Iron deficiency in patients with end stage renal disease (ESRD) treated by haemodialysis (HD) is difficult to diagnose. The reticulocyte hemoglobin content (CHr) and the percentage of hypochromic red cells (%hypo) are sensitive novel assays for the detection of functional iron deficiency in patients treated with erithropoietin (EPO). In our study thirty-nine chronically hemodialyzed patients were evaluated to determine the value of these two parameters in comparison to the conventional biochemical indicators of iron metabolism. There were significant correlations between CHr and transferrin saturation, CHr and weekly dosage of EPO, and also between %hypo and weekly dosage of EPO. Our data represent superior value of %hypo and CHr to the transferrin saturation and ferritin concentration in detecteng of iron deficiency in HD patients.
