Yukawa E, Satou M, Nonaka T, Yukawa M, Ohdo S, Higuchi S, Kuroda T, Goto Y
Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan.
J Clin Pharm Ther. 2001 Oct;26(5):375-9. doi: 10.1046/j.1365-2710.2001.00372.x.
In antiepileptic drugs, the marked inter- and intrapatient variability of the level-dose ratio makes it difficult to predict serum concentrations from the administered per kg dose. It is therefore important to identify factors, such as age and comedication, that could contribute to this observed variability.
To investigate the effect of age and comedication on clonazepam (CZP) level-dose (L/D) ratios.
A retrospective evaluation of data from 137 epileptic patients who had received clonazepam.
The CZP L/D ratio increased slowly with age up to 15 years in patients on monotherapy. Associated antiepileptic therapy affected the CZP L/D ratio, which was significantly reduced in patients on polytherapy as compared to patients on monotherapy.
The study therefore suggests that routine monitoring of CZP serum levels is extremely useful, especially in the paediatric age group, and in patients who require associated antiepileptic medication.
在抗癫痫药物中，患者间和患者内血药浓度与剂量比值存在显著差异，这使得难以根据每千克给药剂量预测血清浓度。因此，识别诸如年龄和合并用药等可能导致这种差异的因素很重要。
研究年龄和合并用药对氯硝西泮（CZP）血药浓度与剂量（L/D）比值的影响。
对137例接受氯硝西泮治疗的癫痫患者的数据进行回顾性评估。
单药治疗的患者中，CZP的L/D比值在15岁之前随年龄缓慢增加。联合抗癫痫治疗会影响CZP的L/D比值，与单药治疗的患者相比，联合治疗的患者该比值显著降低。
因此，该研究表明，常规监测CZP血清水平非常有用，尤其是在儿童年龄组以及需要联合抗癫痫药物治疗的患者中。
