Meerson F Z, Larionov N P, Krotenko N M
Kardiologiia. 1975 Jan;15(1):107-13.
The dynamics of glycolysis and glycogenolysis in the postnatal period, determined from the accumulation of lactate in the homogenate of the heart muscle, indicates that the glycolytic activity begins to subside right after the birth and becomes constant after a lapse of 15-20 days. The activity of the phosphorylase, phosphohexoisomerase, enolase and pyruvate-kinase in the heart muscle extract was found to remain virtually unchanged. Some decline is noted in the activity of the aldolase and hexokinase, while that of the phosphofructokinase and lactate-dehydrogenase rises by 50-60 per cent. These data suggest that in the early ontogenesis the increasing capacity of the mitochondrial system in the heart muscle is paralled by an adjustable conditioned inhibition of the glycolytic phosphorylation, with concurrently rising activity of the phosphofructokinas and, consequently, also of the potential capacity of glycolysis and glycogenolysis.
根据心肌匀浆中乳酸的积累情况确定的出生后时期糖酵解和糖原分解的动态变化表明，糖酵解活性在出生后立即开始下降，并在15 - 20天后变得恒定。发现心肌提取物中的磷酸化酶、磷酸己糖异构酶、烯醇化酶和丙酮酸激酶的活性实际上保持不变。醛缩酶和己糖激酶的活性略有下降，而磷酸果糖激酶和乳酸脱氢酶的活性则上升了50 - 60%。这些数据表明，在个体发育早期，心肌中线粒体系统能力的增加与糖酵解磷酸化的可调节条件性抑制并行，同时磷酸果糖激酶的活性增加，因此糖酵解和糖原分解的潜在能力也增加。
