Krasnowska M, Zak-Nejmark T, Krasnowski R
Katedra i Klinika Chorób Wewnetrznych i Alergologii AM we Wrocławiu.
Pol Arch Med Wewn. 2001 Mar;105(3):211-5.
Heparin and its derivatives exhibit a wide spectrum of biological functions affecting adhesion, activation and trafficking of leukocytes. The aim of that study was to investigate whether heparins are chemoattractants for neutrophils from peripheral blood of healthy volunteers and if chemotactic effects are identical in the same concentrations of unfractionated heparin and 3 low molecular weight heparin-nadroparin, enoxaparin and reviparin. We found that heparins are chemoatractants for neutrophils with potency comparable to fMLP known chemoatractant. Chemotaxis elucidated by identical doses by unfractionated heparin differed significantly from that after reviparin and enoxaparin.
肝素及其衍生物具有广泛的生物学功能，可影响白细胞的黏附、活化和运输。该研究的目的是调查肝素是否是健康志愿者外周血中性粒细胞的趋化剂，以及在相同浓度的普通肝素和3种低分子量肝素（那屈肝素、依诺肝素和瑞肝素）中趋化作用是否相同。我们发现肝素是中性粒细胞的趋化剂，其效力与已知的趋化剂fMLP相当。普通肝素相同剂量引发的趋化作用与瑞肝素和依诺肝素后的趋化作用有显著差异。
