Kostova I P, Manolov I I, Nicolova I N, Danchev N D
Department of Chemistry, Faculty of Pharmacy, Medical University, Sofia, Bulgaria.
Farmaco. 2001 Sep;56(9):707-13. doi: 10.1016/s0014-827x(01)01109-0.
Complexes of copper (II), zinc (II), nickel (II), cobalt (II) and iron (III) with 4-methyl-7-hydroxycoumarin sodium salt (Mendiaxon, Hymecromone) were synthesized by mixing of equimolar amounts of the respective metal nitrates and 4-methyl-7-hydroxycoumarin sodium salt in water. The complexes were characterized and identified by elemental analysis, conductivities, IR, 1H NMR spectroscopy and mass spectral data. DTA and TGA have been applied to study the compositions of the compounds. Thermal analysis of the complexes indicate the formation of compounds which correspond to the compositions Met(HL)2 x nH2O, where Met = Cu, Zn, Ni, Co; n = 2, 3 or 4 and Fe(HL)3 x 5H2O. The newly synthesized compounds were assayed for acute intraperitoneal and per oral toxicity, influence on blood clotting time and the most active complex was investigated for spasmolytic activity.
通过在水中将等摩尔量的相应金属硝酸盐与4-甲基-7-羟基香豆素钠盐混合，合成了铜（II）、锌（II）、镍（II）、钴（II）和铁（III）与4-甲基-7-羟基香豆素钠盐（孟地新、羟甲香豆素）的配合物。通过元素分析、电导率、红外光谱、1H核磁共振光谱和质谱数据对配合物进行了表征和鉴定。差示热分析（DTA）和热重分析（TGA）已用于研究化合物的组成。配合物的热分析表明形成了对应于组成Met(HL)2·nH2O的化合物，其中Met = Cu、Zn、Ni、Co；n = 2、3或4，以及Fe(HL)3·5H2O。对新合成的化合物进行了急性腹腔注射和口服毒性试验、对凝血时间的影响试验，并对活性最高的配合物进行了解痉活性研究。
