McMahon F G, Jain A K, Ryan J R, Lefton T E
Clin Pharmacol Ther. 1975 Jan;17(1):79-82. doi: 10.1002/cpt197517179.
Hog mucosal heparin was compared with beef lung heparin in 24 healthy male and female subjects by double-blind crossover study, by both intravenous and subcutaneous routes, to determine their relative anticoagulant effects as estimated by the activated partial thromboplastin test. Both drugs by both routes induced therapeutically comparable anticoagulation effects, without adverse experience. Thus both products are equivalent, unit for unit.
通过双盲交叉研究，在24名健康男性和女性受试者中，经静脉和皮下途径，比较了猪黏膜肝素和牛肺肝素，以活化部分凝血活酶试验评估它们的相对抗凝效果。两种药物经两种途径均诱导出治疗上相当的抗凝效果，且无不良事件。因此，两种产品在单位剂量上是等效的。
