Gillenwater J Y, Westervelt F B, Vaughan E D, Howards S S
Kidney Int. 1975 Mar;7(3):179-86. doi: 10.1038/ki.1975.26.
Differential renal function studies performed on ten patients after release of unilateral hydronephrosis revealed that the previously obstructed kidney exhibits abnormalities in a number of physiological indexes. Many of the obstructed kidneys had an impairment of glomerular filtration rate, concentrating ability, acidification, sodium reabsorption and tubular maximal secretion of para-aminohippurate with normal urinary dilution. Despite impairment of sodium and water reabsorption, none of these patients, nor 20 additional patients, had a significant postobstructive diuresis from the previously obstructed kidney. All of the patients had normal total renal function. Thus, the changes observed were a result of the obstructive injury and were not related to azotemia or aberrations in water or sodium metabolism.
对10例单侧肾盂积水解除后的患者进行的肾功能差异研究显示，先前梗阻的肾脏在多项生理指标上表现异常。许多梗阻的肾脏存在肾小球滤过率、浓缩能力、酸化、钠重吸收以及对氨基马尿酸肾小管最大分泌功能的损害，而尿液稀释功能正常。尽管存在钠和水重吸收功能受损的情况，但这些患者以及另外20例患者中，先前梗阻的肾脏均未出现明显的梗阻后利尿。所有患者的总肾功能均正常。因此，观察到的这些变化是梗阻性损伤的结果，与氮质血症或水钠代谢异常无关。
