Yamaji S, Tennant J, Tandy S, Williams M, Singh Srai S K, Sharp P
Department of Biochemistry and Molecular Biology, Royal Free and University College Medical School, London, UK.
FEBS Lett. 2001 Oct 26;507(2):137-41. doi: 10.1016/s0014-5793(01)02953-2.
Trace metals influence the absorption of each other from the diet and it has been suggested that the divalent metal transporter (DMT1) represents a common uptake pathway for these important micronutrients. However, compelling evidence from our laboratory suggests that DMT1 is predominantly an iron transporter, with lower affinity for other metals. Several studies have shown that increasing dietary iron downregulates DMT1. Interestingly, our current data indicate that zinc upregulates DMT1 protein and mRNA expression and also pH-dependent iron uptake. Transepithelial flux of iron was also increased and was associated with a rise in IREG1 mRNA expression.
痕量金属会影响彼此在饮食中的吸收，有人提出二价金属转运体（DMT1）是这些重要微量营养素的共同摄取途径。然而，我们实验室的有力证据表明，DMT1主要是一种铁转运体，对其他金属的亲和力较低。多项研究表明，增加饮食中的铁会下调DMT1。有趣的是，我们目前的数据表明，锌会上调DMT1蛋白和mRNA表达，以及pH依赖性铁摄取。铁的跨上皮通量也增加了，并且与IREG1 mRNA表达的升高有关。
