Mad与Myc在增殖和分化过程中的相互作用。

The interplay between Mad and Myc in proliferation and differentiation.

作者信息

Zhou Z Q, Hurlin P J

机构信息

Shriners Hospitals for Children, Department of Cell and Developmental Biology, Oregon Health Sciences University, 3101 Sam Jackson Park Road, Portland, OR 97201, USA.

出版信息

Trends Cell Biol. 2001 Nov;11(11):S10-4. doi: 10.1016/s0962-8924(01)02121-3.

DOI:10.1016/s0962-8924(01)02121-3

PMID:11684436

Abstract

Members of the Myc family of transcription factors are key regulators of cell proliferation, and excessive levels of Myc lead to tumor formation. Mad family proteins are related to Myc, but they antagonize the oncogenic activity of Myc in cell-culture assays. Here, we examine current models of Mad function and the relationship between Mad and Myc in cell proliferation, differentiation and tumorigenesis.

摘要

转录因子Myc家族的成员是细胞增殖的关键调节因子，Myc水平过高会导致肿瘤形成。Mad家族蛋白与Myc相关，但在细胞培养实验中，它们会拮抗Myc的致癌活性。在这里，我们研究了当前关于Mad功能的模型以及Mad与Myc在细胞增殖、分化和肿瘤发生中的关系。