细胞衰老作为一种肿瘤抑制机制。

Cellular senescence as a tumor-suppressor mechanism.

作者信息

Campisi J

机构信息

Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.

出版信息

Trends Cell Biol. 2001 Nov;11(11):S27-31. doi: 10.1016/s0962-8924(01)02151-1.

DOI:10.1016/s0962-8924(01)02151-1

PMID:11684439

Abstract

Organisms with renewable tissues had to evolve mechanisms to prevent the development of cancer. One such mechanism is cellular senescence, which irreversibly arrests the growth of cells at risk for neoplastic transformation. Recent findings have revealed the complexities of the senescence phenotype and unexpected possible consequences for the organism.

摘要

具有可再生组织的生物体必须进化出预防癌症发生的机制。其中一种机制是细胞衰老，它能不可逆地阻止有肿瘤转化风险的细胞生长。最近的研究结果揭示了衰老表型的复杂性以及对生物体可能产生的意想不到的后果。