Endo Y, Yamauchi K, Fueta Y, Irie M
Department of Physiology, School of Medicine, University of Occupational and Environmental Health Japan, Kitakyushu, Japan.
Med Sci Monit. 2001 Nov-Dec;7(6):1161-5.
We have reported that only psychological stress, but not physical stress, induces a significant elevation of body temperature following repeated exposures, however, we did not evaluate the effects of psychological stress in an acute case. In this study, we evaluated hormonal and physiological changes caused by an acute exposure to psychological stress in rats, compared to physical stress.
Adult male Wistar rats, weighing 300-400 g, were exposed to foot shock or non-foot shock stress induced by the communication box for 1 h. The rats in the foot shock group received the electrical shock directly, and the rats in the non-foot shock group could escape from the electrical shock, but received various emotional stimuli from other foot-shocked rats in the communication box. Before, during and after the exposure to each stress, we measured body temperature and motor activity by means of the telemetry system, and also measured plasma corticosterone level by radioimmunoassay.
Non-foot shocked rats showed a significant elevation of body temperature (from 37.18 +/- 0.13 degrees C at baseline to the peak, 38.71 +/- 0.10 degrees C), in association with a slight but significant increase in motor activity, and a temporal elevation of plasma corticosterone (from 22.1 +/- 1.6 microg/dl at baseline to 29.5 +/- 2.7 microg/dl). These changes were at a lower magnitude compared to foot shocked rats.
It is concluded that psychological stress, generated by the communication box, could have lower influences as an acute stress than physical stress.
我们曾报道，反复暴露后，只有心理应激而非生理应激会导致体温显著升高，然而，我们并未评估心理应激在急性情况下的影响。在本研究中，我们评估了与生理应激相比，大鼠急性暴露于心理应激所引起的激素和生理变化。
体重300 - 400克的成年雄性Wistar大鼠暴露于由通讯箱诱导的足部电击或非足部电击应激1小时。足部电击组的大鼠直接接受电击，非足部电击组的大鼠可逃避电击，但在通讯箱中受到其他足部电击大鼠的各种情绪刺激。在每次应激暴露前、暴露期间和暴露后，我们通过遥测系统测量体温和运动活动，并通过放射免疫测定法测量血浆皮质酮水平。
非足部电击大鼠的体温显著升高（从基线时的37.18±0.13℃升至峰值38.71±0.10℃），同时运动活动略有但显著增加，血浆皮质酮暂时升高（从基线时的22.1±1.6微克/分升降至29.5±2.7微克/分升）。与足部电击大鼠相比，这些变化的程度较低。
得出的结论是，通讯箱产生的心理应激作为急性应激，其影响可能比生理应激小。
