Högger P, Sorg C
Institute of Pharmaceutical Chemistry, Westfälische Wilhelms-Universität, Münster, Germany.
Biochem Biophys Res Commun. 2001 Nov 9;288(4):841-3. doi: 10.1006/bbrc.2001.5845.
CD163 is a member of the scavenger receptor cysteine-rich family which is expressed exclusively on human monocytes and macrophages. Upon an inflammatory stimulus the protein is shed rapidly from the membranes' surface. CD163 expression is significantly upregulated by glucocorticoids and IL-10. While the membrane-bound form of CD163 was recently identified as scavenger receptor for hemoglobin-haptoglobin complexes, there is no information about a possible role of the shed soluble CD163. It has been suggested earlier that CD163 plays a pivotal role in the downregulatory phase of inflammation. However, it has remained elusive so far as to how this protein might influence the inflammatory process. We have now identified a potential direct anti-inflammatory effect mediated by soluble CD163. The highly purified protein statistically significantly inhibits phorbol ester-induced human T-lymphocyte activation, thus attenuating the immune response to the inflammatory mediator.
CD163是富含半胱氨酸的清道夫受体家族成员，仅在人类单核细胞和巨噬细胞上表达。受到炎症刺激后，该蛋白会迅速从细胞膜表面脱落。糖皮质激素和白细胞介素-10可显著上调CD163的表达。虽然最近已确定膜结合形式的CD163是血红蛋白-触珠蛋白复合物的清道夫受体，但关于可溶性CD163脱落形式可能发挥的作用尚无相关信息。此前有研究表明，CD163在炎症的下调阶段起关键作用。然而，迄今为止，该蛋白如何影响炎症过程仍不清楚。我们现已确定可溶性CD163介导了一种潜在的直接抗炎作用。高度纯化的该蛋白在统计学上可显著抑制佛波酯诱导的人类T淋巴细胞活化，从而减弱对炎症介质的免疫反应。
