Siimes A S, Creasy R K
Am J Obstet Gynecol. 1976 Dec 15;126(8):1003-10. doi: 10.1016/0002-9378(76)90692-x.
Ritodrine hydrochloride was administered parenterally to pregnant ewes during spontaneous or oxytocin-induced uterine activity. The effects of ritodrine on the uterus and cardiovasculature were assessed both with and without simultaneous administration of either alpha or beta blockade. Ritodrine was found to be an effective inhibitor of both spontaneous and induced uterine activity. Ritodrine did cause maternal tachycardia but no significant hypotension. Alpha-adrenergic blockade did not influence the effects of ritodrine. Beta blockade with propranolol reversed the uterine and cardiovascular effects of ritodrine, whereas beta blockade with practolol reversed the cardiovascular effects without interfering with the inhibition of uterine activity produced by ritodrine.
在妊娠母羊出现自发性子宫活动或缩宫素诱发的子宫活动期间，经肠胃外途径给予盐酸利托君。在同时给予α或β受体阻滞剂和未给予的情况下，评估了利托君对子宫和心血管系统的影响。结果发现，利托君是自发性和诱发性子宫活动的有效抑制剂。利托君确实引起了母体心动过速，但未导致明显的低血压。α肾上腺素能阻滞剂不影响利托君的作用。普萘洛尔进行β受体阻滞可逆转利托君对子宫和心血管系统的作用，而醋氨心安进行β受体阻滞可逆转心血管系统的作用，而不干扰利托君对子宫活动的抑制作用。
