Karaburun Paker S, Kilicarslan B, Ciftcioglu A M, Oztekin S, Sargin F C, Erdogru T, Baykara M
The Faculty of Medicine, Department of Pathology, Akdeniz University, Antalya, Turkey.
Pathol Oncol Res. 2001;7(3):209-12. doi: 10.1007/BF03032351.
Cellular proliferation programmed cell death (apoptosis) are associated with tumor growth in general, and prostate cancer growth in particular. The aim of this study was to examine the expression of the apoptosis regulating genes bcl-2 and p53 and Gleason score in core needle biopsy specimens of prostate cancer using immunohistochemistry. We studied bcl-2 and p53 expression in 12 cases of low grade (Gleason score 2-5), 12 cases of intermediate grade (Gleason score 6-7) and 8 cases of high grade (Gleason score 8-10) prostate cancer. Overexpression of bcl-2 was noted in 3 of 32 patients (9.32%). One of them was high grade; others were intermediate grades. Expression of p53 was observed in 3 of low grades; others were high grade. The statistical analysis of present data suggest that there is no significant relation between p53 and bcl-2 expression and Gleason score in prostate cancer.
细胞增殖和程序性细胞死亡（凋亡）通常与肿瘤生长相关，尤其是前列腺癌的生长。本研究的目的是使用免疫组织化学方法检测前列腺癌粗针穿刺活检标本中凋亡调节基因bcl-2和p53的表达以及Gleason评分。我们研究了12例低级别（Gleason评分2-5）、12例中级别（Gleason评分6-7）和8例高级别（Gleason评分8-10）前列腺癌中bcl-2和p53的表达。32例患者中有3例（9.32%）出现bcl-2过表达。其中1例为高级别，其他为中级别。低级别中有3例观察到p53表达；其他为高级别。对当前数据的统计分析表明，前列腺癌中p53和bcl-2表达与Gleason评分之间无显著关系。
