Liberski P P, Giraud P, Kopp N
Department of Molecular Biology, Chair of Oncology, Medical Academy Lódź, Poland.
Folia Neuropathol. 2000;38(4):171-3.
In this study we examined well fixed brain biopsies of 9 sporadic CJD, 9 iatrogenic CJD cases, 2 hereditary CJD (Gly200Lys and Val203Iso), a case of vCJD and a case of fatal familial insomnia (FFI) from a new French family collected over the years at the Service de Neuropathologie, Hopital Neurologique, Lyon, France. Tubulovesicular structures (TVS) were found in every case including FFI and nvCJD. Thus, TVS, as we suggested previously are important pathologic structure which significance should be more extensively studied.
在本研究中，我们检查了多年来在法国里昂神经病医院神经病理学服务部收集的9例散发性克雅氏病、9例医源性克雅氏病、2例遗传性克雅氏病（甘氨酸200赖氨酸和缬氨酸203异亮氨酸）、1例变异型克雅氏病以及1例来自一个新的法国家庭的致死性家族性失眠症患者的固定良好的脑活检样本。在包括致死性家族性失眠症和变异型克雅氏病在内的每一例中均发现了管状囊泡结构（TVS）。因此，正如我们之前所指出的，管状囊泡结构是重要的病理结构，其意义应得到更广泛的研究。
Zotero 插件