Papadopoulos N, Tamiolakis D, Lambropoulou M, Alexiadis G, Argyropoulou P, Manavis J, Verettas D, Sivridis E
Department of Pathology, Democritus University of Thrace, Dragana, 68 100 Alexandroupolis, Greece.
In Vivo. 2001 Jul-Aug;15(4):359-64.
Ewing's sarcoma arising in the right fibula was diagnosed in a 12 years old female, considering clinical presentation, radiological findings and histological features. Our work points towards a possible neuroectodermal origin of Ewing's sarcoma, since MIC2/12E7 marker was found to be positive. Translocation t (11;22) (q24;q12) was found as the main cytogenetic change in this tumor, by means of FISH analysis.
一名12岁女性被诊断出右腓骨发生尤因肉瘤，诊断依据为临床表现、放射学检查结果及组织学特征。由于发现MIC2/12E7标记物呈阳性，我们的研究表明尤因肉瘤可能起源于神经外胚层。通过荧光原位杂交（FISH）分析发现，该肿瘤的主要细胞遗传学改变为t（11；22）（q24；q12）易位。
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