Arkel Y S, Ku D H
Maine Medical Center Research Institute, Maine Medical Center, Scarborough 04074, USA.
Clin Appl Thromb Hemost. 2001 Oct;7(4):259-68. doi: 10.1177/107602960100700402.
The association of thrombophilia with pregnancy complications has received increasing attention. It is now apparent that thrombophilia is responsible for a large number of the serious complications of pregnancy such as venous thrombosis, pulmonary embolism, fetal loss, pregnancy loss, intrauterine fetal demise, and preeclampsia. The inherited thrombophilia abnormalities, factor V Leiden mutation, prothrombin gene mutation 20210A, and antithrombin III, protein C, and protein S deficiency, and the acquired disorders, the anticardiolipin syndrome and lupus inhibitor, are responsible for a large share of the incidences of premature termination of pregnancy and many of the above complications. The normal physiology of pregnancy may be prothrombotic, with evidence for increased markers of activated coagulation and coagulation factors. There is a decrease in protein S and resistance to activated protein C occurs in a significant number of pregnancies in the absence of the factor V Leiden mutation. In the following article, we review some of the major studies that have correlated the thrombophilia and other acquired disorders that adversely impact pregnancies.
血栓形成倾向与妊娠并发症之间的关联已受到越来越多的关注。现在很明显，血栓形成倾向是导致大量妊娠严重并发症的原因，如静脉血栓形成、肺栓塞、胎儿丢失、妊娠丢失、宫内胎儿死亡和先兆子痫。遗传性血栓形成倾向异常，即因子V莱顿突变、凝血酶原基因突变20210A以及抗凝血酶III、蛋白C和蛋白S缺乏，以及获得性疾病，即抗心磷脂综合征和狼疮抗凝物，在很大程度上导致了妊娠过早终止的发生率以及上述许多并发症。妊娠的正常生理状态可能具有促血栓形成作用，有证据表明活化凝血标志物和凝血因子增加。在没有因子V莱顿突变的情况下，大量妊娠中蛋白S减少且对活化蛋白C产生抵抗。在接下来的文章中，我们回顾了一些将血栓形成倾向与其他对妊娠产生不利影响的获得性疾病相关联的主要研究。
