强调衰老。
Putting the stress on senescence.
作者信息
Serrano M, Blasco M A
机构信息
Department of Immunology and Oncology, National Center of Biotechnology (CSIC), Campus de Cantoblanco, Madrid E-28049, Spain.
出版信息
Curr Opin Cell Biol. 2001 Dec;13(6):748-53. doi: 10.1016/s0955-0674(00)00278-7.
Abstract
Cultivation of primary cells over many generations eventually results in a reproducible loss of proliferative potential that has been termed 'replicative senescence'. Recent work has revealed the heterogeneity of senescence. Importantly, the analysis of the various aspects and types of senescence has turned out to be very informative about numerous in vivo processes, and particularly about carcinogenesis.
摘要
原代细胞经过多代培养最终会导致增殖潜能出现可重复性丧失，这一现象被称为“复制性衰老”。最近的研究揭示了衰老的异质性。重要的是，对衰老的各个方面和类型进行分析已被证明对于众多体内过程，尤其是对于癌症发生过程，具有很大的参考价值。
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