Keef K D, Hume J R, Zhong J
Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557, USA.
Am J Physiol Cell Physiol. 2001 Dec;281(6):C1743-56. doi: 10.1152/ajpcell.2001.281.6.C1743.
High voltage-activated Ca(2+) channels of the Ca(V)1.2 class (L-type) are crucial for excitation-contraction coupling in both cardiac and smooth muscle. These channels are regulated by a variety of second messenger pathways that ultimately serve to modulate the level of contractile force in the tissue. The specific focus of this review is on the most recent advances in our understanding of how cardiac Ca(V)1.2a and smooth muscle Ca(V)1.2b channels are regulated by different kinases, including cGMP-dependent protein kinase, cAMP-dependent protein kinase, and protein kinase C. This review also discusses recent evidence regarding the regulation of these channels by protein tyrosine kinase, calmodulin-dependent kinase, purified G protein subunits, and identification of possible amino acid residues of the channel responsible for kinase regulation.
Ca(V)1.2 类（L 型）的高电压激活 Ca(2+) 通道对心肌和平滑肌的兴奋-收缩偶联至关重要。这些通道受多种第二信使途径调节，这些途径最终用于调节组织中的收缩力水平。本综述的具体重点是我们对心脏 Ca(V)1.2a 和平滑肌 Ca(V)1.2b 通道如何受不同激酶调节的最新认识进展，这些激酶包括 cGMP 依赖性蛋白激酶、cAMP 依赖性蛋白激酶和蛋白激酶 C。本综述还讨论了关于这些通道受蛋白酪氨酸激酶、钙调蛋白依赖性激酶、纯化的 G 蛋白亚基调节的最新证据，以及鉴定通道中可能负责激酶调节的氨基酸残基。
