Yamanaka H, Izawa H, Okamoto K
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro, Tokushima 770-8514, Japan.
J Bacteriol. 2001 Dec;183(23):6961-4. doi: 10.1128/JB.183.23.6961-6964.2001.
The Escherichia coli TolC acts as a channel tunnel in the transport of various molecules across the outer membrane. Partial-deletion studies of tolC revealed that the region extending from the 50th to the 60th amino acid residue from the carboxy terminus plays an important role in this transport activity of TolC.
大肠杆菌的TolC在各种分子跨外膜运输过程中充当通道隧道。对tolC的部分缺失研究表明,从羧基末端起第50至60个氨基酸残基延伸的区域在TolC的这种运输活性中起重要作用。