泼尼松诱导血小板功能异常时的止血作用。

Prednisone-induced hemostasis in a platelet function abnormality.

作者信息

Hutter J J, Hathaway W E

出版信息

Am J Dis Child. 1975 May;129(5):641-3. doi: 10.1001/archpedi.1975.02120420073022.

DOI:10.1001/archpedi.1975.02120420073022

Abstract

A 6-year old girl had chronic thrombocytopenia and substantial platelet function abnormality associated with detectable IgM antiplatelet antibody. Treatment with prednisone was followed by an improvement in bleeding time, although in vitro platelet function deteriorated. This observation suggests an effect of prednisone on hemostasis that is independent of platelet function. Further trials of prednisone in patients with similar platelet function abnormalities who have a substantial bleeding tendency would appear indicated.

摘要

一名6岁女孩患有慢性血小板减少症，伴有明显的血小板功能异常，并可检测到IgM抗血小板抗体。使用泼尼松治疗后，出血时间有所改善，尽管体外血小板功能恶化。这一观察结果表明泼尼松对止血有独立于血小板功能的作用。对于有明显出血倾向且血小板功能异常的患者，似乎有必要进一步试验泼尼松。

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