短暂性新生儿低钙血症、低镁血症以及伴有母亲甲状旁腺功能亢进的高血清甲状旁腺激素
Transient neonatal hypocalcemia, hypomagnesemia, and high serum parathyroid hormone with maternal hyperparathyroidism.
作者信息
Monteleone J A, Lee J B, Tashjian A H, Cantor H E
出版信息
Ann Intern Med. 1975 May;82(5):670-2. doi: 10.7326/0003-4819-82-5-670.
Findings in a case of neonatal tetany in a child whose mother had elevated blood parathyroid hormone levels because of a parathyroid adenoma are given. The child was found to have hypocalcemia, hypomagnesemia, and hyperphosphatemia. Parathyroid hormone in the infant was found to be elevated. It has been postulated that the pathophysiologic mechanism of the hypocalcemia in this syndrome is transient hypoparathyroidism. The present case suggests a different mechanism: hypomagnesemia and end-organ refractoriness to parathyroid hormone, a state analogous to pseudohypoparathyroidism.
本文报告了一例新生儿手足搐搦症病例，患儿母亲因甲状旁腺腺瘤导致血甲状旁腺激素水平升高。该患儿出现低钙血症、低镁血症和高磷血症。检测发现婴儿的甲状旁腺激素水平升高。据推测，该综合征低钙血症的病理生理机制为暂时性甲状旁腺功能减退。本病例提示了一种不同的机制：低镁血症和终末器官对甲状旁腺激素不应性，一种类似于假性甲状旁腺功能减退的状态。
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