Sudi K M, Gallistl S, Tröbinger M, Payerl D, Aigner R, Borkenstein M H
Institute for Sport Sciences, Karl-Franzens University, Graz, Austria.
Metabolism. 2001 Nov;50(11):1323-9. doi: 10.1053/meta.2001.27230.
The pattern of subcutaneous fat (SAT) is related to metabolic risk factors in obese children. Because weight loss improves the risk-factor profile, we sought to determine whether changes in SAT or SAT-pattern contribute to the improvement in the risk-factor profile after 3 weeks of a low-calorie diet and physical activities. In 22 obese boys (mean age, 11.9 years) and 40 obese girls (mean age, 12 years), fat mass (by means of impedance) and fat distribution (waist and hip circumference) were assessed. The thickness of 15 different subcutaneous adipose tissue layers (SAT-layers) was measured using a Lipometer (Moeller Messtechnik, Graz, Austria). SAT and SAT-pattern (arm-SAT, trunk-SAT, leg-SAT) were calculated. Blood samples were taken for the determination of insulin, glucose, triglycerides, and cholesterol. After 3 weeks, fat mass, waist and hip circumference, SAT, arm-SAT, trunk-SAT (all P <.0001), and leg-SAT (P <.01) were reduced. Besides glucose, metabolic parameters were lowered (all P <.001) but changes in metabolic parameter were interrelated in boys and girls. Age- and sex-adjusted regression revealed that changes in body mass contributed to the variability in changes of insulin (adjusted R(2) =.15, P =.0015). For the change in triglycerides, changes in cholesterol together with subtle alterations in glucose and changes in leg-SAT were found to be the main determinants (adjusted R(2) =.587, P <.0001). The results indicate that the change in the atherogenic and metabolic risk factor profile is largely independent from the concomitant loss in SAT. The reduction in body mass explained only a small part of the variability in changes of insulin, but leg-SAT might participate in the lowering of triglycerides, especially in boys. The contribution of SAT-pattern to the risk factor profile is an issue that needs further investigation.
皮下脂肪（SAT）模式与肥胖儿童的代谢危险因素相关。由于体重减轻可改善危险因素状况，我们试图确定在进行3周低热量饮食和体育活动后，SAT或SAT模式的变化是否有助于改善危险因素状况。对22名肥胖男孩（平均年龄11.9岁）和40名肥胖女孩（平均年龄12岁）进行了脂肪量（通过阻抗法）和脂肪分布（腰围和臀围）评估。使用脂肪测量仪（奥地利格拉茨的默勒测量技术公司）测量15个不同皮下脂肪组织层（SAT层）的厚度。计算SAT和SAT模式（手臂SAT、躯干SAT、腿部SAT）。采集血样以测定胰岛素、葡萄糖、甘油三酯和胆固醇。3周后，脂肪量、腰围和臀围、SAT、手臂SAT、躯干SAT（均P<.0001）以及腿部SAT（P<.01）均有所减少。除葡萄糖外，代谢参数均降低（均P<.001），但男孩和女孩的代谢参数变化相互关联。年龄和性别校正回归显示，体重变化导致胰岛素变化存在差异（校正R² =.15，P =.0015）。对于甘油三酯变化，发现胆固醇变化以及葡萄糖的细微改变和腿部SAT变化是主要决定因素（校正R² =.587，P<.0001）。结果表明，致动脉粥样硬化和代谢危险因素状况的变化在很大程度上独立于SAT的同时减少。体重减轻仅解释了胰岛素变化差异的一小部分，但腿部SAT可能参与甘油三酯的降低，尤其是在男孩中。SAT模式对危险因素状况的贡献是一个需要进一步研究的问题。
