在用人绝经期促性腺激素进行控制性卵巢过度刺激过程中，雄激素代谢的5α-还原酶和芳香化酶途径之间的平衡发生改变。

Altered balance between the 5 alpha-reductase and aromatase pathways of androgen metabolism during controlled ovarian hyperstimulation with human menopausal gonadotropins.

作者信息

Slater C C, Chang L, Stanczyk F Z, Paulson R J

机构信息

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

出版信息

J Assist Reprod Genet. 2001 Oct;18(10):527-33. doi: 10.1023/a:1011914218410.

DOI:10.1023/a:1011914218410

PMID:11699123

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3455317/

Abstract

PURPOSE

To evaluate androgen production and metabolism during controlled ovarian hyperstimulation.

METHODS

Five women, aged 33-42, were studied. All participants were undergoing controlled ovarian hyperstimulation with gonadotropin-releasing hormone agonist and human menopausal gonadotropins. Serum estradiol, estrone, androstenedione, testosterone, 3 alpha-androstanediol glucuronide, and sex hormone-binding globulin levels were measured at 6 time points during the cycle.

RESULTS

The levels of all steroids increased significantly from baseline during controlled ovarian hyperstimulation. Mean total testosterone levels increased from 0.29 +/- 0.05 ng/mL to 0.58 +/- 0.07 ng/mL after gonadotropin stimulation. Sex hormone-binding gonadotropin levels increased from 50 +/- 16 nM to 73 +/- 12 nM after gonadotropin stimulation. Estrone/androstenedione and estradiol/testosterone ratios, reflecting the aromatase pathway, increased whereas 3 alpha-androstanediol glucuronide/androstenedione and 3 alpha-androstanediol glucuronide/testosterone ratios, reflecting 5 alpha-reductase activity, decreased.

CONCLUSIONS

Controlled ovarian hyperstimulation with human menopausal gonadotropins results in increased serum testosterone and androstenedione levels. Whereas there is an enhancement in androgen metabolism by aromatase, 5 alpha-reductase activity with regard to androgen metabolism is diminished.

摘要

目的

评估控制性卵巢刺激过程中的雄激素生成及代谢情况。

方法

对5名年龄在33 - 42岁的女性进行研究。所有参与者均接受促性腺激素释放激素激动剂和人绝经期促性腺激素进行控制性卵巢刺激。在月经周期的6个时间点测量血清雌二醇、雌酮、雄烯二酮、睾酮、3α - 雄烷二醇葡萄糖醛酸苷和性激素结合球蛋白水平。

结果

在控制性卵巢刺激过程中，所有类固醇水平均较基线显著升高。促性腺激素刺激后，总睾酮平均水平从0.29±0.05 ng/mL升至0.58±0.07 ng/mL。促性腺激素刺激后，性激素结合球蛋白水平从50±16 nM升至73±12 nM。反映芳香化酶途径的雌酮/雄烯二酮和雌二醇/睾酮比值升高，而反映5α - 还原酶活性的3α - 雄烷二醇葡萄糖醛酸苷/雄烯二酮和3α - 雄烷二醇葡萄糖醛酸苷/睾酮比值降低。