苗勒管异常对体外受精结局的影响。
Effects of Mullerian anomalies on in vitro fertilization outcome.
作者信息
Attia K I, Hug-Koronya M, Ginsburg E S, Hornstein M D
机构信息
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
J Assist Reprod Genet. 2001 Oct;18(10):544-7. doi: 10.1023/a:1011950202480.
PURPOSE
To assess the effect of Mullerian anomalies on pregnancy rates in women undergoing in vitro fertilization (IVF).
METHODS
The records of 37 patients with and 819 patients without Mullerian anomalies undergoing a first cycle of IVF between December 1995 and July 1998 were included in this retrospective study. Outcome variables included maximal estradiol level, number of days of stimulation, number of follicles, number of oocytes, fertilization rate, and ongoing/livebirth pregnancy rate.
RESULTS
Patients with Mullerian anomalies had a significantly lower ongoing pregnancy rate (8.3%) than did controls (24.8%). No patients with diethylstilbestrol (DES)-related anomalies had an ongoing pregnancy.
CONCLUSIONS
Among women with Mullerian anomalies, those with DES exposure in utero demonstrated the poorest outcome.
目的
评估苗勒管异常对接受体外受精（IVF）女性妊娠率的影响。
方法
本回顾性研究纳入了1995年12月至1998年7月期间首次接受IVF治疗的37例有苗勒管异常的患者及819例无苗勒管异常的患者。观察指标包括最高雌二醇水平、刺激天数、卵泡数、卵母细胞数、受精率以及持续妊娠/活产妊娠率。
结果
有苗勒管异常的患者持续妊娠率（8.3%）显著低于对照组（24.8%）。没有使用己烯雌酚（DES）相关异常的患者实现持续妊娠。
结论
在有苗勒管异常的女性中，子宫内暴露于DES的患者预后最差。
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